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The Complete Guide to Testosterone Therapy for Postmenopausal Women

Daniel Stickler MD's avatar
Daniel Stickler MD
Jul 10, 2025
∙ Paid

Did you know that testosterone is the most abundant hormone in reproductive females, much more than estrogen! And postmenopausal women report much higher life satisfaction when they get testosterone and estrogen replacement than estrogen replacement alone.

Here's something most gynecologists aren't talking about yet but should be testosterone therapy, both systemic and vaginal, is emerging as a game-changing option for peri- and postmenopausal women struggling with everything from sexual dysfunction to recurrent UTIs to muscle weakness.

If you're a woman who can't use estrogen, whether due to breast cancer history, blood clot risk, or personal preference or if estrogen alone isn't addressing your symptoms, this could be the answer you've been searching for.

Part 1: Vaginal Testosterone - The Local Solution

The Clinical Evidence That's Changing Everything:

The recently published PIVoT trial results from the Sexual Medicine Society of North America are remarkable. In this randomized, double-blind, placebo-controlled study of 44 postmenopausal women with frequent UTIs, vaginal testosterone cream produced measurable improvements that placebo couldn't match.

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